The contribution presents a system concept for digital teaching and learning environments, which includes current media concepts and enables a pedagogy that is only possible through the use of new digital interactive media. The concepts for this learning environment have been based on contemporary pedagogical theories in awareness that learning processes are going to be less dependent on teaching technologies and content and more on active processes of learning itself. A platform and environment called Ambient Learning Spaces (ALS) has been developed in a series of research projects, which enables individuals as well as groups of learners to create, share, distribute, and reuse semantically annotated media in a social teaching and learning process. The Network Environment for Multimedia Objects (NEMO) forms the technological backend for different ALS frontend learning applications. It contains a semantically modelled, cloud-based repository for rich media applications and allows the creation of semantically annotated multimedia content to be used across these applications. These applications can be used on mobile or stationary interactive systems such as domes, large screens, tangibles, mobiles, and wearables. The media like text, image, video, or 3D can be reused in the different learning applications and will be adapted automatically for various interaction devices with different media capabilities. Interaction methods depending on the available devices reach from direct manipulation interfaces on touch displays to augmented reality or 360° interactive virtual reality applications. In the ALS-Portal, learners include and edit their own media and annotate them semiautomatically. Teachers select and manage the learning applications and prepare the teaching content and logic for their pedagogical purposes. The learning applications support both stationary and mobile learning, all based on NEMO and its semantic media repository. Special user interfaces like tangible media and large multitouch screens as well as mobile media and wearables enable bodyand spacerelated learning in real life contexts inside and outside of school. Based on pedagogical approaches and requirements, the contribution describes the structure and function of the platform and gives an overview of the different learning applications together with evaluation results. Besides the school context, ALS has been used in museums.